P4-099: GASTROINTESTINAL (GI) TRACT MICROBIOME-MEDIATED UP-REGULATION OF MICRORNA-146A IN SPORADIC ALZHEIMER'S DISEASE BRAIN
نویسندگان
چکیده
منابع مشابه
Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer’s Disease
The first indication of a potential mechanistic link between the pathobiology of the human gastrointestinal (GI)-tract microbiome and its contribution to the pathogenetic mechanisms of sporadic Alzheimer's disease (AD) came a scant 4 years ago (1). Ongoing research continues to strengthen the hypothesis that neurotoxic microbial-derived components of the GI tract microbiome can cross aging GI t...
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1 LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA 2 Department of Microbiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA 3 Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA 4 Alchem Biotek, Toronto, ON, Canada 5 Department of Neurology, Louisiana State University He...
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The modern molecular biology movement was developed in the 1960s with the conglomeration of biology, chemistry, and physics. Today, molecular biology is an integral part of studies aimed at understanding the evolution and ecology of gastrointestinal microbial communities. Molecular techniques have led to significant gains in our understanding of the chicken gastrointestinal microbiome. New adva...
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Increasing evidence supports the involvement of microRNAs (miRNA) in the regulation of inflammation in human neurological disorders. In the present study we investigated the role of miR-146a, a key regulator of the innate immune response, in the modulation of astrocyte-mediated inflammation. Using Taqman PCR and in situ hybridization, we studied the expression of miR-146a in epilepsy-associated...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2019
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2019.06.3759